Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

KM Jamsen; SB Duffull; J Tarning; N Lindegardh; N White; JA Simpson

Journal article

Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

KM Jamsen, SB Duffull, J Tarning, N Lindegardh, N White, JA Simpson

Malaria Journal | BMC | Published : 2011

DOI: 10.1186/1475-2875-10-181

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Abstract

Background: Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not formally considered. This could lead to imprecise estimates of the target PK parameters, and/or designs insufficient to estimate all of the parameters. Optimal design methodology has been developed to determine blood sampling schedules that will yield precise parameter estimates within the practical constraints of sampling the study populations. In this work optimal design methods were used to determine sampling designs for typical future popu..

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University of Melbourne Researchers

Julie Simpson Author

Related Projects (1)

Design of Antimalarial Pharmacokinetic Studies

Each year there are more than 500 million episodes of malaria and over a million deaths. One of the main causes of this burden is inadequate..

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Awarded by Wellcome Trust

Funding Acknowledgements

This work was funded by a project grant from the National Health and Medical Research Council (NHMRC; 566855). KMJ is funded by a NHMRC PhD scholarship. The Mahidol-Oxford Tropical Medicine Research Unit and the PKPDia collaboration are supported by the Wellcome Trust. We would like to thank Prof Richard Price from the Menzies School of Health Research, Darwin, Australia for reviewing the survey that was emailed to the malaria researchers.